Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNPAT | O15228 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.51 |
| ▸ | CASP9 | P55211 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | NPY4R | P50391 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | CPA2 | P48052 | 1/20 | 0.47 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277518 | 0.88 | CASP3 (0.58) | GNPATCASP3CASP7CASP1CASP9 | |
| SCHEMBL7277400 | 0.84 | CASP3 (0.53) | GNPATCASP3CASP7CASP1CASP9 | |
| SCHEMBL7296845 | 0.84 | GNPAT (0.47) | GNPATCASP3CASP7CASP1CASP9 | |
| SCHEMBL11040848 | 0.83 | OPRK1 (0.54) | GNPATOPRD1NPY1RNPY2RNPY4R | |
| SCHEMBL11040843 | 0.83 | OPRK1 (0.54) | GNPATOPRD1NPY1RNPY2RNPY4R | |
| SCHEMBL7410461 | 0.82 | CASP3 (0.46) | GNPATCASP3CASP7CASP1CASP9 | |
| SCHEMBL9565155 | 0.81 | CTSD (0.47) | CASP3CASP7OPRD1CASP1CASP9 | |
| SCHEMBL24520152 | 0.80 | BACE1 (0.58) | CASP1 | |
| SCHEMBL29350612 | 0.80 | ACE (0.58) | OPRD1 | |
| SCHEMBL31243875 | 0.80 | OPRM1 (0.53) | GNPATOPRD1NPY1RNPY2RNPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533350-B1 | DNA encoding precursor interleukin 1B converting enzyme | MERCK & CO INC (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0519748-B1 | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme | MERCK & CO INC (US) | 1998-09-02 | — | — | EP | disclosed |
| EP-0648128-A4 | DNA ENCODING PRECURSOR INTERLEUKIN 1-g(b) CONVERTING ENZYME. | MERCK & CO INC (US) | 1995-07-26 | — | — | EP | disclosed |
| US-5434248-A | Peptidyl derivatives as inhibitors of interleukin-1β converting enzyme | MERCK & CO., INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0648128-A1 | DNA ENCODING PRECURSOR INTERLEUKIN 1$g(b) CONVERTING ENZYME | MERCK & CO. INC. (US) | 1995-04-19 | — | — | EP | disclosed |
| US-5278061-A | Affinity chromatography matrix useful in purifying interleukin-1β converting enzyme | MERCK & CO., INC. (US) | 1994-01-11 | — | — | US | disclosed |
| WO-1994000154-A1 | DNA ENCODING PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0533350-A1 | DNA encoding precursor interleukin 1B converting enzyme | MERCK & CO. INC. (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0529713-A1 | Affinity chromatography matrix useful in purifying interleukin-1B converting enzyme | MERCK & CO. INC. (US) | 1993-03-03 | — | — | EP | disclosed |