Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275478 | 0.85 | CHRNB4 (0.39) | FAAHCHRNB4CHRNA3GSK3AGSK3B | |
| SCHEMBL7274379 | 0.85 | FAAH (0.39) | FAAHCHRNB4CHRNA3GSK3AGSK3B | |
| SCHEMBL7275324 | 0.85 | CHRNB4 (0.39) | FAAHCHRNB4CHRNA3GSK3AGSK3B | |
| SCHEMBL7282793 | 0.83 | ALDH1A1 (0.45) | GSK3AGSK3BSIGMAR1ALDH1A1MEN1 | |
| SCHEMBL7281548 | 0.82 | FAAH (0.36) | FAAHCHRNB4CHRNA3ALDH1A1DRD2 | |
| SCHEMBL7283442 | 0.82 | GAA (0.39) | FAAHCHRNB4CHRNA3GSK3AGSK3B | |
| SCHEMBL7272984 | 0.81 | CHRNB4 (0.39) | FAAHCHRNB4CHRNA3SIGMAR1ALDH1A1 | |
| SCHEMBL7273909 | 0.81 | TDP1 (0.44) | GSK3AGSK3BALDH1A1KMT2ATSHR | |
| SCHEMBL7274156 | 0.80 | ABCB1 (0.42) | CHRNB4CHRNA3MEN1KMT2AOPRM1 | |
| SCHEMBL7282764 | 0.80 | ABCB1 (0.42) | CHRNB4CHRNA3MEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |