Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275324 | 0.86 | CHRNB4 (0.39) | CHRNB4CHRNA3FAAHALDH1A1NPC1 | |
| SCHEMBL7275478 | 0.86 | CHRNB4 (0.39) | CHRNB4CHRNA3FAAHALDH1A1NPC1 | |
| SCHEMBL7274379 | 0.86 | FAAH (0.39) | CHRNB4CHRNA3OPRM1FAAHALDH1A1 | |
| SCHEMBL7273681 | 0.86 | ALDH1A1 (0.44) | OPRM1OPRD1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7283442 | 0.83 | GAA (0.39) | CHRNB4CHRNA3FAAHTSHRNPC1 | |
| SCHEMBL7274559 | 0.82 | OPRM1 (0.39) | OPRM1SIGMAR1KCNH2 | |
| SCHEMBL7276423 | 0.81 | FAAH (0.37) | CHRNB4CHRNA3OPRM1FAAHALDH1A1 | |
| SCHEMBL7273909 | 0.80 | TDP1 (0.44) | ALDH1A1TSHRSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7272672 | 0.79 | ALDH1A1 (0.39) | OPRM1FAAHALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL7274062 | 0.79 | ALDH1A1 (0.39) | OPRM1ALDH1A1SMN1; SMN2SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |