Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7267531 | 0.87 | KMO (0.52) | MKNK1MKNK2CACNA1BDHODHKMO | |
| SCHEMBL9434755 | 0.85 | CACNA1B (0.45) | MKNK1MKNK2CACNA1BKMOMAPT | |
| SCHEMBL9401812 | 0.84 | CACNA1B (0.65) | CACNA1BMAPT | |
| SCHEMBL10432705 | 0.84 | CACNA1B (0.44) | MKNK1MKNK2CACNA1BKMOLMNA | |
| SCHEMBL9434417 | 0.83 | MAPT (0.45) | MKNK1MKNK2CACNA1BMEN1MAPT | |
| SCHEMBL9434316 | 0.83 | CACNA1B (0.44) | MKNK1MKNK2CACNA1BKMOMAPT | |
| SCHEMBL9433919 | 0.83 | CACNA1B (0.44) | MKNK1MKNK2CACNA1BKMOLMNA | |
| SCHEMBL8781993 | 0.83 | MKNK1 (0.52) | MKNK1MKNK2DHODHKMOPIM1 | |
| SCHEMBL9433821 | 0.81 | ALDH1A1 (0.46) | CACNA1BLMNAKMT2A | |
| SCHEMBL9434041 | 0.81 | CACNA1B (0.42) | MKNK1MKNK2CACNA1BKMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373645-B1 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4 -dihyropyridines and process for their preparation | PHARMACIA SPA (IT) | 1995-04-19 | — | — | EP | claimed |
| EP-0403627-A1 | IMIDAZOLYL AND PYRIDYL DERIVATIVES OF PHENYL SUBSTITUTED 1,4-DIHYDRO-PYRIDINES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1990-12-27 | — | — | EP | claimed |
| EP-0373645-A1 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4 -dihyropyridines and process for their preparation | PHARMACIA S.p.A. (IT) | 1990-06-20 | — | — | EP | claimed |
| US-5514693-A | THROMBOXANE A2 SYNTHETASE INHIBITOR, CALCIUM ANTAGONIST | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-05-07 | — | — | US | disclosed |
| EP-0373645-B1 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4 -dihyropyridines and process for their preparation | PHARMACIA SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| EP-0403627-A1 | IMIDAZOLYL AND PYRIDYL DERIVATIVES OF PHENYL SUBSTITUTED 1,4-DIHYDRO-PYRIDINES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1990-12-27 | — | — | EP | disclosed |
| WO-1990006923-A1 | IMIDAZOLYL AND PYRIDYL DERIVATIVES OF PHENYL SUBSTITUTED 1,4-DIHYDRO-PYRIDINES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1990-06-28 | — | — | WO | disclosed |
| EP-0373645-A1 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4 -dihyropyridines and process for their preparation | PHARMACIA S.p.A. (IT) | 1990-06-20 | — | — | EP | disclosed |