Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801435 | 0.73 | MEN1 (0.51) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL1647924 | 0.72 | LMNA (0.47) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL18801320 | 0.71 | LMNA (0.47) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL18801179 | 0.69 | LMNA (0.45) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL13870607 | 0.69 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL28104591 | 0.69 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL1648072 | 0.69 | MAPT (0.47) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL131249 | 0.69 | CA12 (0.57) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL18796174 | 0.68 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1MAPK1LMNAMAPT | |
| SCHEMBL18801332 | 0.67 | L3MBTL1 (0.52) | ALDH1A1L3MBTL1MAPK1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4918087-A | 2-thiomethyl-substituted-pyridine and -3,5-dicarboxylates having anti-hypertensive activity | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1990-04-17 | — | — | US | disclosed |
| EP-0282904-A2 | 2-Thiomethyl-substituted-pyridines, a method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-09-21 | — | — | EP | disclosed |