Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7301912 | 0.98 | METAP2 (0.42) | METAP2ASIC3MAPKAPK2RPS6KA3CSNK2A1 | |
| Hydrochloric Acid SCHEMBL7349133 | 0.98 | METAP2 (0.42) | METAP2ASIC3MAPKAPK2RPS6KA3CSNK2A1 | |
| SCHEMBL7398132 | 0.91 | VCP (0.40) | METAP2CHEK1ALDH1A1MAPTNPC1 | |
| SCHEMBL7398136 | 0.82 | POLB (0.55) | TP53MEN1MAPTKMT2ANPC1 | |
| SCHEMBL13575692 | 0.81 | NPC1 (0.45) | MAPKAPK2MAPTNPC1SMN1; SMN2PDE3B | |
| SCHEMBL695196 | 0.81 | CYP1A2 (0.46) | METAP2ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL31226596 | 0.81 | METAP2 (0.50) | METAP2CHEK1ALDH1A1MEN1MAPT | |
| SCHEMBL1395492 | 0.81 | METAP2 (0.50) | METAP2CHEK1ALDH1A1MEN1MAPT | |
| SCHEMBL9669035 | 0.81 | PRKAB2 (0.35) | MAPTMAP4K4 | |
| SCHEMBL7277812 | 0.77 | NPC1 (0.53) | ALDH1A1TP53MAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | claimed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | claimed |
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |
| EP-0223937-A1 | Indoles substituted with heterocycles, intermediates, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1987-06-03 | — | — | EP | disclosed |
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4632924-A | 5-(4-substituted)phenyl-2-pyrazinones | SMITHKLINE BECKMAN CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0146282-A2 | Pyrazinone compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-26 | — | — | EP | disclosed |
| US-4514568-A | 5-(4-Nitrophenyl)-2(1H)-pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-30 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |