Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391714 | 0.87 | PTPN1 (0.67) | MEN1LMNAPKMKMT2APTPN1 | |
| Bromide SCHEMBL10730898 | 0.86 | PTPN1 (0.65) | MEN1LMNAPKMKMT2APTPN1 | |
| SCHEMBL7396608 | 0.86 | GAA (0.56) | POLBLMNAKMT2APTPN1PTPN6 | |
| SCHEMBL7370129 | 0.86 | PTGS1 (0.50) | PTPN1PTPN6PTPN11PTPN2MAPT | |
| SCHEMBL7366117 | 0.83 | P4HTM (0.53) | POLBMEN1LMNAKMT2APTPN1 | |
| SCHEMBL7398132 | 0.83 | VCP (0.40) | POLBLMNAMAPTNPC1RAB9A | |
| SCHEMBL7278792 | 0.82 | METAP2 (0.43) | MEN1KMT2ATDP1MAPTNPC1 | |
| SCHEMBL7398696 | 0.81 | DYRK1B (0.47) | PTPN1PTPN6PTPN11PTPN2MAPT | |
| Bromide SCHEMBL7301912 | 0.81 | METAP2 (0.42) | MEN1KMT2ATDP1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL7349133 | 0.81 | METAP2 (0.42) | MEN1PKMKMT2ATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | claimed |
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |