Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.66 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.65 |
| ▸ | WNT3A | P56704 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633079 | 0.84 | ADAM17 (0.73) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL15988899 | 0.82 | CTNNB1 (0.65) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL27275913 | 0.81 | CDK4 (0.58) | CTNNB1WNT3APBRM1GPR84ALDH1A1 | |
| SCHEMBL28751191 | 0.80 | GABRA1 (0.81) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL7214385 | 0.80 | ADAM17 (1.00) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL9048121 | 0.80 | ADAM17 (0.71) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL1903034 | 0.79 | ADAM17 (0.66) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL15968498 | 0.79 | CTNNB1 (1.00) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL8959745 | 0.79 | ADAM17 (0.66) | ADAM17CTNNB1WNT3ALMNAPBRM1 | |
| SCHEMBL31588418 | 0.79 | CTNNB1 (0.68) | ADAM17CTNNB1WNT3ALMNAPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814344-A | ANTIEMENTICS, ANTIPSYCHOTICS | GLAXO GROUP LIMITED | 1989-03-21 | — | — | US | disclosed |
| EP-0266899-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1988-05-11 | — | — | EP | disclosed |