Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | PLAU | P00749 | 3/20 | 0.53 |
| ▸ | PLG | P00747 | 3/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.53 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | S100B | P04271 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | AOC1 | P19801 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3241146 | 0.99 | PRSS1 (0.54) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL3192337 | 0.99 | PRSS1 (0.52) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL11936601 | 0.89 | MEN1 (0.38) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL27832557 | 0.88 | PRSS1 (0.49) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL12213745 | 0.87 | GAA (0.53) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL729742 | 0.87 | MEN1 (0.37) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL13686121 | 0.87 | GAA (0.53) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL3666899 | 0.87 | GAA (0.53) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL727316 | 0.87 | MEN1 (0.37) | PRMT1PLAUPLGF2ST14 | |
| SCHEMBL729017 | 0.86 | PRMT1 (0.58) | PRMT1PLAUPLGF2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227496-B2 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | DONG WHA PHARMACEUTICAL CO., LTD (KR) | 2012-07-24 | — | — | US | claimed |
| JP-2011529875-A | — | — | 2011-12-15 | — | — | JP | claimed |
| US-7964584-B2 | Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2011-06-21 | — | — | US | claimed |
| EP-2307015-A2 | A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | Dong Wha Pharmaceutical Co., Ltd. (KR) | 2011-04-13 | — | — | EP | claimed |
| EP-1411935-B1 | USE OF 4- (4-THIAZOLYL)PHENOXL ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM CO LTD (KR) | 2010-05-19 | — | — | EP | claimed |
| US-20100120875-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXY]ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONGWHA PHARMACEUTICAL CO., LTD. | 2010-05-13 | — | — | US | claimed |
| WO-2010013969-A2 | A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2010-02-04 | — | — | WO | claimed |
| US-20100029595-A1 | METHOD OF TREATING OR PREVENTING OSTEOPOROSIS COMPRISING ADMINISTERING TO A PATIENT IN NEED THEREOF AN EFFECTIVE AMOUNT OF PHARMACEUTICAL COMPOSITION COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | DONG WHA PHARM. CO., LTD. (KR) | 2010-02-04 | — | — | US | claimed |
| EP-1773794-A4 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-[5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY]-BENZAMIDINE | DONG WHA PHARM IND CO LTD (KR) | 2009-09-09 | — | — | EP | claimed |
| EP-1773794-A1 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-[5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY]-BENZAMIDINE | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2007-04-18 | — | — | EP | claimed |
| WO-2006004368-A1 | AN IMPROVED PROCESS FOR PREPARING N-HYDROXY-4-{5- [4- (5-ISOPROPYL-2-METHYL-l, 3-THIAZOL-4-YL) -PHENOXY] -PENTOXY }-BENZAMIDINE | DONG WHA PHARMACEUTICAL. IND. CO., LTD. (KR) | 2006-01-12 | — | — | WO | claimed |
| EP-1411935-A4 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM IND CO LTD (KR) | 2005-11-09 | — | — | EP | claimed |
| US-20040186150-A1 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | DONG WHA PHARMACEUTICAL CO., LTD. (KP) | 2004-09-23 | — | — | US | claimed |
| EP-1411935-A1 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2004-04-28 | — | — | EP | claimed |
| WO-2003007947-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2003-01-30 | — | — | WO | claimed |
| CN-102149380-B | A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt | DONG WHA PHARM CO LTD | 2012-12-05 | — | — | CN | disclosed |
| US-8242152-B2 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for the prophylaxis and treatment of osteoporosis | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2012-08-14 | — | — | US | disclosed |
| EP-1411935-A1 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003007947-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003007947-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2003-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186150-A1 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | LTB4R, LTB4R2, CYSLTR1 | PRMT1 1085/4885PLAU 1161/4885PLG 989/4885 |
| US-20100120875-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXY]ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | SOST, THPO, BMP4 | PRMT1 1326/4885PLAU 670/4885PLG 701/4885 |
| US-20100029595-A1 | METHOD OF TREATING OR PREVENTING OSTEOPOROSIS COMPRISING ADMINISTERING TO A PATIENT IN NEED THEREOF AN EFFECTIVE AMOUNT OF PHARMACEUTICAL COMPOSITION COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | SOST, PTH1R, BPGM | PRMT1 1416/4885PLAU 429/4885PLG 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.