Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.36 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727316 | 1.00 | MEN1 (0.37) | MEN1KMT2APRMT1F2ST14 | |
| SCHEMBL729234 | 0.99 | MEN1 (0.38) | MEN1KMT2APRMT1F2ST14 | |
| SCHEMBL727594 | 0.97 | MEN1 (0.38) | MEN1KMT2APLAUPLGTMPRSS2 | |
| SCHEMBL1685013 | 0.95 | MEN1 (0.36) | MEN1KMT2APRMT1F2ST14 | |
| SCHEMBL3175452 | 0.95 | MEN1 (0.36) | MEN1KMT2APRMT1F2ST14 | |
| SCHEMBL729392 | 0.93 | MEN1 (0.36) | MEN1KMT2APLAUPLGPRSS1 | |
| SCHEMBL727828 | 0.92 | GCGR (0.35) | MEN1KMT2APRMT1F2ST14 | |
| SCHEMBL729307 | 0.92 | MEN1 (0.36) | MEN1KMT2ADRD3HRH3HDAC1 | |
| SCHEMBL727800 | 0.91 | HDAC1 (0.35) | MEN1KMT2AACHEHRH3HDAC1 | |
| SCHEMBL729004 | 0.89 | PRMT1 (0.36) | PRMT1F2ST14PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045581-B | AIE fluorescent probe for detecting copper ions and preparation method and application thereof | 常州大学 | 2022-05-10 | — | — | CN | claimed |
| CN-113045581-A | AIE fluorescent probe for detecting copper ions and preparation method and application thereof | 常州大学 | 2021-06-29 | — | — | CN | claimed |
| JP-2011529875-A | — | — | 2011-12-15 | — | — | JP | claimed |
| US-8039635-B2 | N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl) phenoxy]pentoxy} benzamidine 2 ethansulfonic acid salt, process for the preparation thereof and pharmaceutical composition comprising the same | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2011-10-18 | — | — | US | claimed |
| US-7964584-B2 | Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2011-06-21 | — | — | US | claimed |
| EP-2307015-A2 | A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | Dong Wha Pharmaceutical Co., Ltd. (KR) | 2011-04-13 | — | — | EP | claimed |
| EP-2146974-B1 | N- HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY} BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG WHA PHARM CO LTD (KR) | 2011-01-05 | — | — | EP | claimed |
| US-20100216747-A1 | PREVENTIVE AGENT OR THERAPEUTIC AGENT FOR DISEASE CAUSED BY ABNORMAL BONE METABOLISM | TEIJIN PHARMA LIMITED (JP) | 2010-08-26 | — | — | US | claimed |
| EP-1411935-B1 | USE OF 4- (4-THIAZOLYL)PHENOXL ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM CO LTD (KR) | 2010-05-19 | — | — | EP | claimed |
| US-20100113538-A1 | N-HYDROXY-4- BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2010-05-06 | — | — | US | claimed |
| US-20080214675-A1 | Hydroxybenzoic Acid Amides and the Use Thereof For Masking Bitter Taste | SYMRISE GMBH & CO. KG (DE) | 2008-09-04 | — | — | US | claimed |
| US-20080125596-A1 | Process For Preparing N-Hydroxy-4--Benzamidine | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2008-05-29 | — | — | US | claimed |
| JP-2008508264-A | — | — | 2008-03-21 | — | — | JP | claimed |
| EP-1701722-A4 | N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY¨]PENTOXY}BENZAMIDINE 2 METHANSULFONIC ACID SALT | DONG WHA PHARM IND CO LTD (KR) | 2007-05-16 | — | — | EP | claimed |
| EP-1701722-A1 | N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY¨]PENTOXY}BENZAMIDINE 2 METHANSULFONIC ACID SALT | Dong Wha Pharmaceutical. Ind. Co., Ltd. (KR) | 2006-09-20 | — | — | EP | claimed |
| WO-2006057501-A1 | N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY}BENZAMIDINE 2 METHANSULFONIC ACID SALT | DONG WHA PHARMACEUTICAL. IND. CO., LTD. (KR) | 2006-06-01 | — | — | WO | claimed |
| EP-1411935-A4 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM IND CO LTD (KR) | 2005-11-09 | — | — | EP | claimed |
| US-20040186150-A1 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | DONG WHA PHARMACEUTICAL CO., LTD. (KP) | 2004-09-23 | — | — | US | claimed |
| EP-1411935-A1 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2004-04-28 | — | — | EP | claimed |
| WO-2003007947-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2003-01-30 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186150-A1 | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for treatment of osteoporosis | LTB4R, LTB4R2, CYSLTR1 | MEN1 2817/4885KMT2A 1535/4885PRMT1 1085/4885 |
| US-20100113538-A1 | N-HYDROXY-4- BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | PTMS, HRH4, HRH2 | MEN1 1526/4885KMT2A 1222/4885PRMT1 2628/4885 |
| US-20080125596-A1 | Process For Preparing N-Hydroxy-4--Benzamidine | HNMT, HTR4, PNMT | MEN1 1125/4885KMT2A 613/4885PRMT1 1135/4885 |
| US-20080214675-A1 | Hydroxybenzoic Acid Amides and the Use Thereof For Masking Bitter Taste | TAS1R1, TAS2R1, TAS1R2 | MEN1 1167/4885KMT2A 406/4885PRMT1 665/4885 |
| US-20100216747-A1 | PREVENTIVE AGENT OR THERAPEUTIC AGENT FOR DISEASE CAUSED BY ABNORMAL BONE METABOLISM | BPGM, TLR6, PPARD | MEN1 1365/4885KMT2A 2981/4885PRMT1 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.