Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 5/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319085 | 0.89 | PDE3B (0.67) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL7277959 | 0.83 | PDE3B (0.68) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL3452908 | 0.82 | LMNA (0.80) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL7280366 | 0.81 | PDE3B (1.00) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL482059 | 0.76 | CYP1A2 (1.00) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL9687063 | 0.74 | LMNA (0.69) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL7689907 | 0.74 | CYP1A2 (0.96) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL8695526 | 0.74 | HRH3 (0.55) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL7280452 | 0.74 | PDE3B (0.56) | PDE3APDE3BCYP1A2LMNAMEN1 | |
| SCHEMBL7290613 | 0.73 | CYP1A2 (0.59) | PDE3APDE3BCYP1A2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |