Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279874 | 0.89 | PDE3A (0.68) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL7277959 | 0.82 | PDE3B (0.68) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL3452908 | 0.80 | LMNA (0.80) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL7280366 | 0.80 | PDE3B (1.00) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL9687063 | 0.73 | LMNA (0.69) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL8695526 | 0.73 | HRH3 (0.55) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL7280452 | 0.73 | PDE3B (0.56) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL928205 | 0.72 | LMNA (0.67) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL11035831 | 0.72 | LMNA (1.00) | PDE3BPDE3ALMNAKMT2AMEN1 | |
| SCHEMBL928226 | 0.72 | LMNA (0.67) | PDE3BPDE3ALMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4906628-A | N-phenylpyridone type III phosphodiesterases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-06 | — | — | US | claimed |
| CN-86106546-A | The preparation method of Pyridione derivatives | — | 1987-05-20 | — | — | CN | claimed |
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | claimed |
| US-5246928-A | Cardiovascular disorders | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-21 | — | — | US | disclosed |
| US-5066653-A | Cardiovascular disorders; bronchodilators; phosphodiesterase inhibitors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| CN-1009092-B | The preparation method of Pyridione derivatives | SMITH KLINE FRENCH LAB (GB) | 1990-08-08 | — | — | CN | disclosed |
| US-4906628-A | N-phenylpyridone type III phosphodiesterases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-03-06 | — | — | US | disclosed |
| CN-86106546-A | The preparation method of Pyridione derivatives | — | 1987-05-20 | — | — | CN | disclosed |
| EP-0220044-A2 | 4(4-oxo-1,4-dihydropyridin-1-yl)phenyl derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-04-29 | — | — | EP | disclosed |