Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7279867 | 0.99 | HTR1F (0.43) | HTR1FHTR1ATDO2HTR3AKMT2A | |
| SCHEMBL7271454 | 0.86 | HTR2C (0.44) | HTR1ADRD2MAOAMAOB | |
| Hydrochloric Acid SCHEMBL7272664 | 0.85 | HTR2C (0.43) | HTR1ADRD2MAOAMAOB | |
| SCHEMBL7281834 | 0.85 | MAOA (0.44) | HTR1AHTR3AMAOAMAOB | |
| SCHEMBL7271094 | 0.85 | FAAH (0.47) | HTR3AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7271028 | 0.84 | FAAH (0.46) | HTR3AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7282305 | 0.84 | MAOA (0.44) | HTR1AHTR3AMAOAMAOB | |
| SCHEMBL7278648 | 0.81 | ACHE (0.45) | HTR1AHTR3AMAOAMAOB | |
| Hydrochloric Acid SCHEMBL7280360 | 0.80 | ACHE (0.44) | HTR1AHTR3AKMT2AMAOAMAOB | |
| SCHEMBL7282325 | 0.77 | ALDH1A1 (0.47) | HTR3AKMT2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643923-A | TREATMENT OF ANXIETY, COGNITION ACTIVATORS, SENILITY OR ALZHEIMER'S | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0456519-B1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| EP-0456519-A1 | Piperidyloxy- and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use | Sankyo Company Limited (JP) | 1991-11-13 | — | — | EP | disclosed |