Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277012 | 0.92 | KDM4E (0.45) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL8892804 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL7274948 | 0.78 | GPR119 (0.40) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL189570 | 0.74 | FPR2 (0.51) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL7384022 | 0.73 | NR1H2 (0.46) | KDM4EGAAGPR119FAAHDPP4 | |
| Hydrochloric Acid SCHEMBL7284384 | 0.73 | KDM4E (0.42) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL7350839 | 0.72 | HPGD (0.46) | KDM4EALDH1A1GAATSHRSMN1; SMN2 | |
| SCHEMBL7323448 | 0.71 | GPR119 (0.41) | KDM4EGPR119FAAHPKMHPGD | |
| SCHEMBL8634128 | 0.71 | KDM4E (0.46) | KDM4EGPR119FAAHPKMHPGD | |
| SCHEMBL7385084 | 0.71 | KDM4E (0.46) | KDM4EGPR119FAAHPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512831-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5455243-A | Anticoagulants | MERCK & CO., INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5281585-A | Secondary amide containing antagonist | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1992019595-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512831-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |