Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7291612 | 0.89 | LMNA (0.52) | HPGDNPC1ALDH1A1LMNADPP4 | |
| SCHEMBL7290887 | 0.82 | PKM (0.57) | CYP3A4CYP2C9PKMCYP2C19HPGD | |
| SCHEMBL7265568 | 0.80 | HPGD (0.52) | CYP3A4CYP2C9PKMCYP2C19HPGD | |
| SCHEMBL7292109 | 0.78 | ALDH1A1 (0.47) | CYP2C9ALDH1A1EPHX2 | |
| SCHEMBL9569384 | 0.78 | ALDH1A1 (0.47) | CYP2C9ALDH1A1EPHX2 | |
| SCHEMBL9446939 | 0.75 | PKM (0.52) | CYP3A4CYP2C9PKMCYP2C19HPGD | |
| SCHEMBL7304558 | 0.73 | LMNA (0.49) | ALDH1A1LMNADPP4DPP8DPP7 | |
| SCHEMBL8304030 | 0.73 | ACE (0.36) | DPP4DPP7 | |
| SCHEMBL9872738 | 0.73 | GAA (0.47) | PKMHPGDALDH1A1 | |
| SCHEMBL9872741 | 0.73 | GAA (0.47) | PKMHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537802-B1 | N-acylpyrrolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO (JP) | 1999-08-25 | — | — | EP | claimed |
| EP-0537802-A2 | N-acylpyrrolidines and N-acylthiazolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-21 | — | — | EP | claimed |
| EP-0345428-A1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-13 | — | — | EP | claimed |