Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.51 |
| ▸ | ECE1 | P42892 | 9/20 | 0.51 |
| ▸ | MME | P08473 | 9/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284698 | 1.00 | ACE2 (0.51) | ACE2ECE1MMEMMP2MMP7 | |
| SCHEMBL7308401 | 0.98 | ECE1 (0.53) | ACE2ECE1MMEMMP2MMP7 | |
| SCHEMBL7286158 | 0.88 | MMP2 (0.48) | ACE2ECE1MMEMMP2MMP7 | |
| SCHEMBL10718415 | 0.87 | CTSL (0.44) | ECE1MMEACEREN | |
| SCHEMBL10718426 | 0.87 | CTSL (0.44) | ECE1MMEACEREN | |
| SCHEMBL7277678 | 0.86 | MME (0.48) | ECE1MMEMMP2MMP7MMP9 | |
| SCHEMBL10718705 | 0.86 | REN (0.46) | ECE1MMEMMP2MMP7MMP9 | |
| SCHEMBL7282841 | 0.86 | REN (0.45) | ACE2ECE1MMEMMP2MMP7 | |
| SCHEMBL10716071 | 0.85 | ACE2 (0.67) | ACE2ECE1MME | |
| SCHEMBL7274934 | 0.84 | REN (0.45) | ACE2ECE1MMEMMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |