Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | MMP8 | P22894 | 5/20 | 0.48 |
| ▸ | MMP14 | P50281 | 5/20 | 0.48 |
| ▸ | ANPEP | P15144 | 2/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 3/20 | 0.46 |
| ▸ | MME | P08473 | 5/20 | 0.46 |
| ▸ | ECE1 | P42892 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | MMP11 | P24347 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7277678 | 0.92 | MME (0.48) | MMP2MMP9MMP8MMP14MMP7 | |
| SCHEMBL7277213 | 0.91 | REN (0.44) | MMP2MMP9MMP8ANPEPERAP1 | |
| SCHEMBL7274934 | 0.90 | REN (0.45) | MMP2MMP9MMP8MMP14ANPEP | |
| SCHEMBL10718705 | 0.90 | REN (0.46) | MMP2MMP9MMP8MMP14ANPEP | |
| SCHEMBL10718460 | 0.90 | REN (0.47) | MMP2MMP9MMP8MMP14ANPEP | |
| SCHEMBL7274969 | 0.89 | CTSL (0.45) | RENMMEECE1CTSBCTSK | |
| SCHEMBL7283203 | 0.88 | CTSL (0.43) | MMP2MMP9MMP8MMP14REN | |
| SCHEMBL7284698 | 0.88 | ACE2 (0.51) | MMP2MMP9MMP8MMP14ANPEP | |
| SCHEMBL7283367 | 0.88 | ACE2 (0.51) | MMP2MMP9MMP8MMP14ANPEP | |
| SCHEMBL10718613 | 0.88 | CTSL (0.45) | MMP2MMP9MMP8MMP14REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |