Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367806 | 0.90 | ALDH1A1 (0.38) | MAPTKMT2AKDM4ENPSR1PTGDR2 | |
| SCHEMBL10368214 | 0.88 | MAPT (0.39) | MAPTKMT2AKDM4ENPSR1ALDH1A1 | |
| SCHEMBL27273993 | 0.87 | PDE10A (0.43) | MAPTKDM4ENPSR1ACHEHSD17B3 | |
| SCHEMBL8936714 | 0.83 | HSP90AA1 (0.38) | MAPTKMT2AKDM4ENPSR1PTGDR2 | |
| SCHEMBL9338054 | 0.81 | HSD17B3 (0.38) | MAPTKMT2AKDM4ENPSR1PTGDR2 | |
| SCHEMBL9334812 | 0.81 | GABRA1 (0.48) | MAPTKMT2AKDM4ENPSR1PTGDR2 | |
| SCHEMBL10369526 | 0.81 | KMT2A (0.35) | MAPTKMT2AKDM4ENPSR1NOTUM | |
| SCHEMBL9335063 | 0.81 | GABRA1 (0.40) | MAPTKMT2AKDM4ENPSR1HSD17B3 | |
| SCHEMBL9335056 | 0.81 | GABRA1 (0.36) | MAPTKMT2AKDM4ENPSR1HSD17B3 | |
| SCHEMBL10369849 | 0.79 | HSD17B3 (0.37) | MAPTKMT2AKDM4ENPSR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650966-A1 | Process for the preparation of a benzo(a)quinolizinone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-03 | — | — | EP | claimed |
| EP-0496274-B1 | Tricyclic pyridone derivative | HOFFMANN LA ROCHE (CH) | 1996-07-03 | — | — | EP | disclosed |
| EP-0650966-A1 | Process for the preparation of a benzo(a)quinolizinone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-03 | — | — | EP | disclosed |
| EP-0650966-A1 | Process for the preparation of a benzo(a)quinolizinone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-03 | — | — | EP | disclosed |
| EP-0496274-A1 | Tricyclic pyridone derivative | F. Hoffmann-La Roche AG (CH) | 1992-07-29 | — | — | EP | disclosed |
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |