Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367806 | 0.87 | ALDH1A1 (0.38) | PDE10APDE7APDE3AACHEKDM4E | |
| SCHEMBL7284938 | 0.87 | MAPT (0.40) | PDE10APDE7APDE3AACHEKDM4E | |
| SCHEMBL9335063 | 0.85 | GABRA1 (0.40) | KDM4EOPRK1MAPTHSD17B3PARP1 | |
| SCHEMBL9338217 | 0.84 | ACHE (0.35) | PDE10APDE7APDE3AACHEKDM4E | |
| SCHEMBL9334812 | 0.83 | GABRA1 (0.48) | KDM4EALDH1A1GAAMAPTHSD17B3 | |
| SCHEMBL9335056 | 0.82 | GABRA1 (0.36) | PDE3AKDM4EOPRK1ALDH1A1GAA | |
| SCHEMBL7435251 | 0.81 | CNR1 (0.38) | KDM4EOPRK1ALDH1A1GAAMAPT | |
| SCHEMBL9338054 | 0.81 | HSD17B3 (0.38) | KDM4EMAPTHSD17B3MAPK1PARP1 | |
| SCHEMBL8936714 | 0.81 | HSP90AA1 (0.38) | KDM4EALDH1A1GAAMAPTHSD17B3 | |
| SCHEMBL9338273 | 0.80 | ACHE (0.36) | ACHEKDM4EOPRK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1016871-B | Process for the preparation of bicyclic and tricyclic pyridine derivatives | HOFFMANN LA ROCHE 7 CO F (CN) | 1992-06-03 | — | — | CN | disclosed |