Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284938 | 0.90 | MAPT (0.40) | ALDH1A1MAPTKMT2AKDM4ENPSR1 | |
| SCHEMBL10367683 | 0.89 | MTNR1A (0.41) | ALDH1A1MAPTPOLBKMT2AKDM4E | |
| SCHEMBL27273993 | 0.87 | PDE10A (0.43) | ALDH1A1MAPTKDM4ENPSR1HSD17B3 | |
| SCHEMBL9334812 | 0.84 | GABRA1 (0.48) | ALDH1A1MAPTKMT2AKDM4ENPSR1 | |
| SCHEMBL10369721 | 0.80 | KCNK3 (0.35) | ALDH1A1MAPTKMT2AKDM4ENPSR1 | |
| SCHEMBL8936714 | 0.80 | HSP90AA1 (0.38) | ALDH1A1MAPTKMT2AKDM4ENPSR1 | |
| SCHEMBL10369849 | 0.80 | HSD17B3 (0.37) | MAPTKMT2AKDM4ENPSR1PTGDR2 | |
| SCHEMBL10367826 | 0.80 | AVPR1A (0.37) | ALDH1A1KMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL9335063 | 0.80 | GABRA1 (0.40) | MAPTKMT2AKDM4ENPSR1HSD17B3 | |
| SCHEMBL10367044 | 0.78 | GABRA1 (0.35) | ALDH1A1MAPTPOLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |