Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.47 |
| ▸ | HTR3B | O95264 | 6/20 | 0.47 |
| ▸ | HTR3A | P46098 | 6/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284925 | 0.80 | MEN1 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9199909 | 0.80 | HTR3E (0.61) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7426320 | 0.75 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7279446 | 0.74 | HTR3E (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7305858 | 0.72 | HTR3E (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7305866 | 0.72 | HTR3E (0.48) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7652481 | 0.71 | HTR3A (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7652475 | 0.71 | HTR3A (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL483292 | 0.71 | ALDH1A1 (0.47) | LMNAMAPTSMN1; SMN2RECQLCYP2C19 | |
| SCHEMBL13229696 | 0.70 | MEN1 (0.40) | MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560348-B1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | MITSUBISHI CHEM CORP (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-5352685-A | Gastrointestinal disorders | MITSUBISHI KASEI CORPORATION (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0560348-A1 | Thieno 3,2-b pyridine derivatives for the treatment of gastrointestinal disorders | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |