Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289880 | 0.76 | NPSR1 (0.59) | HTR1AHTR1DHTR1BALDH1A1HPGD | |
| SCHEMBL8250982 | 0.76 | HTR1A (0.60) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL9426432 | 0.75 | GABRA1 (0.69) | GABRA1GABRB2 | |
| SCHEMBL10778563 | 0.75 | HTR1A (0.74) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL17337950 | 0.74 | GABRA1 (0.56) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL11385677 | 0.74 | HTR1A (0.64) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL11385676 | 0.74 | HTR1A (0.64) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL5471393 | 0.72 | HTR1A (0.70) | HTR1AGABRA1GABRB2HTR1DHTR1B | |
| SCHEMBL29018529 | 0.72 | HTR1A (0.78) | HTR1AHTR1DHTR1B | |
| SCHEMBL17337999 | 0.72 | GABRA1 (0.68) | HTR1AGABRA1GABRB2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991645-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 2000-04-12 | — | — | EP | claimed |
| WO-1999000381-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 1999-01-07 | — | — | WO | claimed |
| EP-0887348-A1 | Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them | Boehringer Mannheim Italia S.p.A. (IT) | 1998-12-30 | — | — | EP | claimed |
| EP-0887348-A1 | Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them | Boehringer Mannheim Italia S.p.A. (IT) | 1998-12-30 | — | — | EP | disclosed |