Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7288222 | 1.00 | SIGMAR1 (0.48) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290398 | 0.92 | SIGMAR1 (0.55) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7297357 | 0.79 | SIGMAR1 (0.50) | SIGMAR1DRD2 | |
| SCHEMBL9371956 | 0.78 | SIGMAR1 (0.56) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9373412 | 0.78 | SIGMAR1 (0.51) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7290222 | 0.78 | SIGMAR1 (0.53) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9384282 | 0.77 | CHRNB2 (0.49) | SIGMAR1CYP2D6DRD2TSHR | |
| SCHEMBL7290957 | 0.77 | SIGMAR1 (0.52) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7289331 | 0.77 | SIGMAR1 (0.52) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| Fumaric Acid SCHEMBL9666314 | 0.76 | CYP2D6 (0.45) | SIGMAR1CYP2D6DRD2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412821-B1 | 1-oxa-2-oxo-3,8-diazaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZET (HU) | 1994-11-09 | — | — | EP | disclosed |
| EP-0413516-B1 | 4-Methylene-1-oxa-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZET (HU) | 1994-04-20 | — | — | EP | disclosed |
| EP-0414422-B1 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| EP-0414421-B1 | 1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| EP-0412820-B1 | 2-Oxo-1-oxa-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZET (HU) | 1994-03-02 | — | — | EP | disclosed |
| EP-0414421-A2 | 1-Oxa-2-oxo-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-27 | — | — | EP | disclosed |
| EP-0414422-A2 | 2-Oxo-1-oxa-8-azaspiro [4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-27 | — | — | EP | disclosed |
| EP-0413516-A2 | 4-Methylene-1-oxa-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-20 | — | — | EP | disclosed |
| EP-0412821-A2 | 1-oxa-2-oxo-3,8-diazaspiro[4,5]decane derivatives, pharmaceutical compositions containing them and processes for preparing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-13 | — | — | EP | disclosed |
| EP-0412820-A2 | 2-Oxo-1-oxa-8-azaspiro[4,5] decane derivatives, processes for their preparation and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-02-13 | — | — | EP | disclosed |