Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929283 | 0.87 | SCN4A (0.43) | SCN4ALMNADRD4ALDH1A1MAPT | |
| SCHEMBL7282057 | 0.86 | SCN4A (0.42) | ADRB1SCN4ALMNAALDH1A1MAPT | |
| SCHEMBL22407742 | 0.85 | HTT (0.44) | SCN4ALMNAIDH1DRD4ALDH1A1 | |
| SCHEMBL7446241 | 0.83 | DRD4 (0.40) | ADRB1SCN4ALMNACHRM3DRD4 | |
| SCHEMBL10837562 | 0.82 | HTR7 (0.45) | SCN4ALMNASIGMAR1CHRM5CHRM3 | |
| SCHEMBL209154 | 0.79 | DRD4 (0.61) | LMNASIGMAR1DRD4ALDH1A1 | |
| SCHEMBL7291683 | 0.79 | SIGMAR1 (0.55) | ADRB1LMNASIGMAR1CHRM5CHRM3 | |
| SCHEMBL27887216 | 0.77 | ADRB1 (0.41) | ADRB1LMNASIGMAR1CHRM5CHRM3 | |
| SCHEMBL6644696 | 0.77 | L3MBTL1 (0.45) | LMNASIGMAR1DRD4ALDH1A1 | |
| SCHEMBL5863 | 0.76 | SIGMAR1 (0.56) | LMNASIGMAR1CHRM5CHRM3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |