Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280275 | 0.81 | PDE3B (0.59) | TBXAS1HRH3PDE3BPDE3AMEN1 | |
| SCHEMBL7280421 | 0.79 | PDE3B (0.61) | PDE3BPDE3A | |
| SCHEMBL10196775 | 0.75 | HRH3 (0.66) | HRH3MEN1LMNAKMT2A | |
| SCHEMBL10963711 | 0.75 | LMNA (0.65) | HRH3ALDH1A1MAPK1PDE3BPDE3A | |
| SCHEMBL7306800 | 0.75 | HRH3 (0.62) | HRH3PDE3BPDE3AMEN1LMNA | |
| SCHEMBL3604079 | 0.75 | HRH3 (0.66) | HRH3MAPK1PDE3BPDE3AMEN1 | |
| SCHEMBL1373074 | 0.73 | HRH3 (1.00) | HRH3 | |
| SCHEMBL10750806 | 0.73 | TBXAS1 (0.63) | TBXAS1KDM4EALDH1A1MAPK1MEN1 | |
| Bromide SCHEMBL8110043 | 0.73 | HRH3 (0.63) | HRH3PDE3BPDE3AMEN1LMNA | |
| SCHEMBL8791883 | 0.73 | HRH3 (0.63) | HRH3PDE3BPDE3AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |