Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.49 |
| ▸ | TUBB | P07437 | 5/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381304 | 0.87 | LCK (0.41) | LMNASMN1; SMN2 | |
| SCHEMBL7426404 | 0.79 | MAPK1 (0.46) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7374592 | 0.78 | TUBB4A (0.54) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL212051 | 0.76 | TUBB4A (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4819729 | 0.76 | TUBB4A (0.75) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7290699 | 0.74 | CASP3 (0.42) | LMNA | |
| SCHEMBL7297929 | 0.74 | RORB (0.39) | LMNA | |
| Hydrochloric Acid SCHEMBL27888195 | 0.74 | TUBB4A (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL10273126 | 0.74 | TUBB1 (0.50) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL210357 | 0.72 | LMNA (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486155-B1 | Method of inhibiting neoplastic cells with isoquinoline derivatives | CELL PATHWAYS INC | 2002-11-26 | — | — | US | disclosed |
| WO-1998038168-A1 | ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-03 | — | — | WO | disclosed |