Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.57 |
| ▸ | HTR2A | P28223 | 16/20 | 0.57 |
| ▸ | HTR1A | P08908 | 10/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD5 | P21918 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.55 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283232 | 0.88 | DRD2 (0.72) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL7323722 | 0.83 | DRD2 (0.75) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL7292040 | 0.82 | DRD2 (0.79) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL7293956 | 0.80 | ADRA2A (0.59) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL10924509 | 0.79 | ADRA1D (0.48) | DRD2HTR2AHTR1AADRA1DSLC6A4 | |
| SCHEMBL7697170 | 0.75 | DRD2 (0.53) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL9492109 | 0.75 | DRD2 (0.51) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL9202999 | 0.75 | DRD2 (0.51) | DRD2HTR2AHTR1AADRA2AADRA2B | |
| SCHEMBL12786171 | 0.74 | DRD2 (0.53) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL10952899 | 0.74 | HTR1A (0.51) | DRD2HTR2AHTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196132-B1 | 1,2-BENZISOXAZOL-3-YL AND 1,2-BENZISOTHIAZOL-3-YL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-12 | — | — | EP | disclosed |
| US-4804663-A | PSYCHOLOGICAL DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-02-14 | — | — | US | disclosed |
| EP-0196132-A2 | 1,2-Benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-01 | — | — | EP | disclosed |