Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS2 | Q9UI32 | 3/20 | 0.44 |
| ▸ | PDCD4 | Q53EL6 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293046 | 1.00 | GLS2 (0.44) | GLS2PDCD4ALOX5PPARGFAAH | |
| SCHEMBL7293103 | 0.85 | PDCD4 (0.40) | GLS2PDCD4PPARGFAAH | |
| SCHEMBL7296440 | 0.80 | PDCD4 (0.41) | PDCD4 | |
| SCHEMBL8621126 | 0.78 | ALOX5 (0.44) | GLS2PDCD4ALOX5FAAH | |
| SCHEMBL8616293 | 0.78 | ALOX5 (0.44) | GLS2PDCD4ALOX5FAAH | |
| SCHEMBL9422785 | 0.78 | CTSK (0.45) | — | |
| SCHEMBL9422783 | 0.78 | CTSK (0.45) | — | |
| SCHEMBL7303157 | 0.77 | ALDH1A1 (0.36) | PDCD4 | |
| SCHEMBL8745838 | 0.75 | ALOX5 (0.40) | GLS2PDCD4ALOX5FAAH | |
| SCHEMBL8985076 | 0.74 | PDCD4 (0.47) | GLS2PDCD4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | claimed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | claimed |
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5376676-A | Process of using anti-inflammatory furanones as selective calcium channel inhibitors | ALLERGAN, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |