Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22434856 | 0.81 | ADORA3 (0.50) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8002000 | 0.81 | KDM4E (0.61) | MAPK14CCNB2CDK1CCNB1CCNA2 | |
| SCHEMBL29445964 | 0.81 | CYP2D6 (0.45) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL19396824 | 0.79 | DYRK1A (0.43) | MAPK14MAPK13MAPK12MAPK11CCNB2 | |
| SCHEMBL3141937 | 0.78 | ASIC3 (0.41) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| Lofemizole SCHEMBL35441 | 0.78 | ADORA3 (0.47) | CCNB2CDK1CCNB1CDK5CDK5R1 | |
| SCHEMBL21428970 | 0.78 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5717900 | 0.77 | KIF11 (0.42) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL2691682 | 0.77 | CYP2A6 (0.56) | MAPTLMNAKDM4ECYP3A4 | |
| SCHEMBL17675495 | 0.77 | IDO1 (0.47) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024123967-A1 | SARM1 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | SENYA PHARMACEUTICALS, INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| EP-0507650-B1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1996-05-22 | — | — | EP | disclosed |
| US-5434169-A | Piperidine derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1995-07-18 | — | — | US | disclosed |
| US-5418241-A | Antiserotonin agents | SYNTHELABO (FR) | 1995-05-23 | — | — | US | disclosed |
| EP-0646583-A1 | Derivatives of Imidezol-4-yl piperidine, their preparation and use in therapy | SYNTHELABO (FR) | 1995-04-05 | — | — | EP | disclosed |
| EP-0591027-A1 | Piperidine derivatives, their preparation and their use as medicine | SYNTHELABO (FR) | 1994-04-06 | — | — | EP | disclosed |
| EP-0591026-A1 | Piperidine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-04-06 | — | — | EP | disclosed |
| US-5280030-A | Containing 1-benz(oxazole, thiazole or imidazole)-4-imidazole piperidine compound | SYNTHELABO (FR) | 1994-01-18 | — | — | US | disclosed |
| EP-0507650-A1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1992-10-07 | — | — | EP | disclosed |