Lofemizole

Lofemizole

SCHEMBL35441

Cc1[nH]cnc1-c1ccc(Cl)cc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.45
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
AKT2 P31751 2/20 0.41
PRKACA P17612 1/20 0.41
PRKACG P22612 1/20 0.41
PRKACB P22694 1/20 0.41
IKBKB O14920 1/20 0.41
MAP3K14 Q99558 1/20 0.41
AKT1 P31749 2/20 0.40
NPY5R Q15761 1/20 0.40
SLC9A1 P19634 1/20 0.39
KDM4E B2RXH2 2/20 0.38
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
CCNB2 O95067 1/20 0.38
CDK1 P06493 1/20 0.38
CCNB1 P14635 1/20 0.38
GSK3A P49840 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lofemizole SCHEMBL44549 0.98 SMN1; SMN2 (0.47) ADORA3SMN1; SMN2ADORA2AADORA1AKT2
SCHEMBL22434856 0.83 ADORA3 (0.50) ADORA3SMN1; SMN2ADORA2AADORA1KDM4E
SCHEMBL21428970 0.80 MAPK14 (0.54) SMN1; SMN2KDM4ECYP3A4MAPTERBB2
SCHEMBL4866745 0.79 PIK3CD (0.43) KDM4ECYP3A4CCNB2CDK1CCNB1
SCHEMBL8002000 0.79 KDM4E (0.61) ADORA3SMN1; SMN2ADORA2AADORA1AKT2
SCHEMBL7295129 0.78 MAPK14 (0.51) KDM4ECYP3A4MAPTCCNB2CDK1
SCHEMBL4075858 0.78 KDM4E (0.64) ADORA3ADORA2AADORA1AKT2PRKACA
SCHEMBL5717900 0.76 KIF11 (0.42)
SCHEMBL15444885 0.74 HSD11B1 (0.46) KDM4EMAPT
SCHEMBL18612329 0.74 NISCH (0.41) SMN1; SMN2AKT2PRKACAPRKACGPRKACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3279663-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2021-07-28 EP claimed
EP-2001496-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2017-05-31 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20120183600-A1 NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS CHEN CHIEN-HUNG (US) 2012-07-19 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
US-4499104-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTICONVULSANT AGENTS FARMATIS S.R.L. (IT) 1985-02-12 US claimed
US-20260061093-A1 LIPID ANALOGS, LIPOSOMES COMPRISING SAME AND USES THEREOF LIPOSPHERE LTD. (IL) 2026-03-05 US disclosed
US-20250304667-A1 COMPLEMENT COMPONENT C5 ANTIBODIES ALLERGAN INC (US) 2025-10-02 US disclosed
EP-3693381-B1 LIGAND BINDING MOLECULES AND USES THEREOF VEGENICS PTY LTD (AU) 2025-09-03 EP disclosed
EP-4580693-A1 LIPID ANALOGS, LIPOSOMES COMPRISING SAME AND USES THEREOF Liposphere Ltd. (IL) 2025-07-09 EP disclosed
EP-0136893-A2 Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them MERCK FROSST CANADA INC. (CA) 1985-04-10 EP disclosed
US-4499104-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTICONVULSANT AGENTS FARMATIS S.R.L. (IT) 1985-02-12 US disclosed
US-4499104-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTICONVULSANT AGENTS FARMATIS S.R.L. (IT) 1985-02-12 US disclosed
EP-0123541-A1 Leukotriene antagonists MERCK FROSST CANADA INC. (CA) 1984-10-31 EP disclosed
EP-0123543-A1 Leukotriene antagonists, their production and use and compositions containing them MERCK FROSST CANADA INC. (CA) 1984-10-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260061093-A1 LIPID ANALOGS, LIPOSOMES COMPRISING SAME AND USES THEREOF PHOSPHO1, SGMS1, SGMS2 ADORA3 3429/4885SMN1; SMN2 4231/4885ADORA2A 3872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.