Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293090 | 0.88 | EDNRA (0.37) | EDNRAEDNRB | |
| SCHEMBL7304769 | 0.88 | EDNRA (0.37) | EDNRAEDNRB | |
| SCHEMBL7302716 | 0.83 | MAPK14 (0.35) | LMNAHTTGAA | |
| SCHEMBL8322002 | 0.80 | EDNRA (0.46) | EDNRALMNAHTTGAAEDNRB | |
| SCHEMBL8322432 | 0.77 | LMNA (0.41) | EDNRALMNAHTTGAA | |
| SCHEMBL7387930 | 0.76 | EDNRA (0.38) | EDNRAEDNRB | |
| SCHEMBL7301959 | 0.76 | EDNRA (0.38) | EDNRAEDNRB | |
| SCHEMBL7330283 | 0.74 | DHPS (0.46) | EDNRALMNAHTTEDNRB | |
| SCHEMBL7295217 | 0.73 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL9423670 | 0.73 | EDNRA (0.66) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | claimed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |