Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP12 | P39900 | 3/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13135968 | 0.73 | HSD17B10 (0.42) | ALDH1A1MMP1MMP9MMP12MMP2 | |
| SCHEMBL7285809 | 0.71 | GPR84 (0.41) | GPR84ALDH1A1MMP1MMP9MMP12 | |
| SCHEMBL7285845 | 0.67 | MMP1 (0.35) | GPR84SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL1441267 | 0.65 | GPR84 (0.57) | GPR84MMP1MMP9MMP12 | |
| SCHEMBL7295809 | 0.65 | MAPK8 (0.37) | SMN1; SMN2NPC1ALDH1A1RAB9AADRA2A | |
| SCHEMBL10567467 | 0.65 | MAPK8 (0.37) | SMN1; SMN2NPC1ALDH1A1RAB9AADRA2A | |
| SCHEMBL11531010 | 0.64 | MEN1 (0.53) | SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL7293169 | 0.63 | MMP1 (0.35) | GPR84SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL24886104 | 0.60 | MMP1 (0.41) | GPR84SMN1; SMN2ALDH1A1MMP1MMP9 | |
| SCHEMBL8885478 | 0.58 | GPR84 (0.72) | GPR84MMP1MMP9MMP12DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863938-A | Pyridine derivatives and their use as nootropic agents | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | claimed |
| EP-0239533-B1 | PYRIDINE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-16 | — | — | EP | disclosed |
| US-4863938-A | Pyridine derivatives and their use as nootropic agents | CIBA-GEIGY CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |