Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804170 | 0.85 | DYRK1A (0.66) | CDK2MAP3K14CDK4DYRK1APKM | |
| SCHEMBL73445 | 0.78 | MIF (0.60) | CDK2MIFPRKACADYRK1APKM | |
| SCHEMBL18606919 | 0.77 | MIF (0.58) | CDK2MIFDYRK1APKMFLT3 | |
| SCHEMBL25789350 | 0.76 | MIF (0.57) | MIFPRKACADYRK1APKMFLT3 | |
| SCHEMBL21208172 | 0.76 | KIT (0.61) | CDK2MIFPRKACADYRK1APKM | |
| SCHEMBL25789356 | 0.75 | MIF (0.56) | MIFPRKACADYRK1APKMFLT3 | |
| SCHEMBL4202167 | 0.75 | HSP90AA1 (0.76) | CDK2HSP90AA1MAP3K14AURKAPRKACA | |
| SCHEMBL2650330 | 0.73 | FLT3 (0.74) | MIFPRKACADYRK1APKMFLT3 | |
| SCHEMBL14138786 | 0.73 | MIF (0.60) | CDK2MIFCDK4PRKACADYRK1A | |
| SCHEMBL29109646 | 0.73 | FLT3 (0.69) | MIFPRKACADYRK1APKMFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |