Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 11/20 | 0.47 |
| ▸ | PPARA | Q07869 | 9/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296368 | 1.00 | MEN1 (0.48) | MEN1KMT2AHTR2APPARGPPARA | |
| SCHEMBL28707283 | 0.79 | PPARG (0.62) | PPARGPPARA | |
| SCHEMBL6443753 | 0.78 | MGLL (0.54) | KMT2AHTR2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7370462 | 0.78 | HTR2A (0.51) | HTR2ASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL7418355 | 0.78 | HTR2A (0.57) | MEN1KMT2AHTR2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6322393 | 0.77 | SMN1; SMN2 (0.64) | KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL20377184 | 0.77 | SMN1; SMN2 (0.64) | KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7509723 | 0.77 | MMP1 (0.53) | MEN1KMT2ASMN1; SMN2NPC1TP53 | |
| SCHEMBL7509712 | 0.77 | MMP1 (0.53) | MEN1KMT2ASMN1; SMN2NPC1TP53 | |
| SCHEMBL1714950 | 0.77 | HTR2A (0.70) | MEN1KMT2AHTR2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151513-A | N-HETEROCYCLIC ALCOHOL DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1992-09-29 | — | — | US | disclosed |
| EP-0341481-A1 | N-heterocyclic alcohol derivatives | E.R. Squibb & Sons, Inc. (US) | 1989-11-15 | — | — | EP | disclosed |