Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.57 |
| ▸ | CTSS | P25774 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10432018 | 0.92 | CTSK (0.53) | CTSKCTSSCTSLCTSBPSMB1 | |
| SCHEMBL7294855 | 0.91 | CTSK (0.52) | CTSKCTSSCTSLCTSBPSMB1 | |
| SCHEMBL7321385 | 0.86 | TRPM8 (0.55) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7428630 | 0.86 | TRPM8 (0.55) | CTSKCTSSCTSLCTSB | |
| SCHEMBL10432035 | 0.86 | CTSK (0.52) | CTSKCTSSCTSLCTSBPSMB1 | |
| SCHEMBL7429348 | 0.84 | CTSS (0.52) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7399913 | 0.84 | CTSS (0.52) | CTSKCTSSCTSLCTSB | |
| SCHEMBL8353955 | 0.83 | CTSK (0.62) | CTSKCTSSCTSLCTSBPSMB1 | |
| SCHEMBL14011286 | 0.82 | CTSK (0.64) | CTSKCTSSCTSLCTSBACE2 | |
| SCHEMBL10431940 | 0.82 | CTSK (0.48) | CTSKCTSSCTSLCTSBPSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368719-B1 | Novel analogs of peptidase substrates | MERRELL PHARMA INC (US) | 1997-01-08 | — | — | EP | disclosed |
| US-5114927-A | Hypotensive agents and inhibiting renin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0371179-A1 | Novel analogs of peptidase substrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0368719-A2 | Novel analogs of peptidase substrates | MERRELL PHARMACEUTICALS INC. (US) | 1990-05-16 | — | — | EP | disclosed |
| EP-0362002-A1 | HIV protease inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-04 | — | — | EP | disclosed |
| EP-0356595-A1 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| EP-0275101-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-20 | — | — | EP | disclosed |