Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.64 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.60 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303034 | 0.87 | NR1H4 (0.54) | ST14ITGB3ITGA2BCA12CA1 | |
| SCHEMBL7380405 | 0.87 | F10 (0.58) | ST14ITGB3ITGA2BF2HDAC2 | |
| SCHEMBL7118598 | 0.86 | ITGB3 (0.74) | ST14ITGB3ITGA2BF2CA1 | |
| SCHEMBL7304057 | 0.86 | ITGB3 (0.56) | ST14ITGB3ITGA2BF2TPSAB1 | |
| Hydrochloric Acid SCHEMBL9271862 | 0.85 | ITGB3 (0.55) | ST14ITGB3ITGA2BF2TPSAB1 | |
| SCHEMBL7303344 | 0.85 | ST14 (0.59) | ST14ITGB3ITGA2BF2CA12 | |
| Hydrochloric Acid SCHEMBL9272571 | 0.84 | ST14 (0.58) | ST14ITGB3ITGA2BF2CA12 | |
| SCHEMBL11470600 | 0.83 | ESRRG (0.68) | HDAC2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL9335737 | 0.83 | TPSAB1 (0.67) | ST14ITGB3ITGA2BF2CA1 | |
| SCHEMBL7303302 | 0.83 | ITGB3 (0.66) | ST14ITGB3ITGA2BF2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381033-B1 | Carboxylic-acid and sulphonic-acid amides | HOFFMANN LA ROCHE (CH) | 1994-03-23 | — | — | EP | claimed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | claimed |
| US-5399585-A | Anitcoagulants, antiinflammatory, antitumor | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5256812-A | Antitumor agents, cardiovascular disorders; having amidino or guandino groups | HOFFMANN-LA ROCHE INC. (US) | 1993-10-26 | — | — | US | disclosed |
| US-5084466-A | Anticoagulants, antiinflammatory agents, atheriosclerosis and antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1992-01-28 | — | — | US | disclosed |