Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.71 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.71 |
| ▸ | DPP4 | P27487 | 4/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304997 | 0.83 | ITGB3 (0.80) | ITGB3ITGA2B | |
| SCHEMBL7297075 | 0.83 | ITGB3 (1.00) | ITGB3ITGA2B | |
| SCHEMBL7306246 | 0.81 | ITGB3 (0.77) | ITGB3ITGA2B | |
| SCHEMBL19974607 | 0.80 | YAP1 (0.54) | ITGB3ITGA2BSIGMAR1 | |
| SCHEMBL8643671 | 0.79 | DPP4 (0.55) | ITGB3ITGA2BDPP4CD274NAMPT | |
| SCHEMBL9225481 | 0.78 | ITGB3 (0.71) | ITGB3ITGA2BSIGMAR1 | |
| SCHEMBL7299486 | 0.76 | EPHX2 (0.58) | DPP4SIGMAR1CD274NAMPTDHODH | |
| SCHEMBL8880311 | 0.72 | ITGB3 (0.48) | ITGB3ITGA2BDPP4CCR3CHRM4 | |
| SCHEMBL7753402 | 0.72 | FFAR4 (0.52) | DPP4CHRM4SIGMAR1 | |
| SCHEMBL16616770 | 0.70 | NAMPT (0.67) | DPP4CCR3CHRM4NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |