Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | ADH5 | P11766 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099792 | 0.81 | MEN1 (0.54) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL11097731 | 0.78 | NPC1 (0.50) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL2533488 | 0.77 | TSHR (0.84) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL28239036 | 0.76 | ENPP2 (0.89) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL2532397 | 0.75 | LMNA (0.78) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL328792 | 0.74 | ENPP2 (1.00) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| Hydrochloric Acid SCHEMBL28701756 | 0.73 | LMNA (0.75) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL14624862 | 0.73 | MAPT (0.51) | ENPP2MKNK1MKNK2MEN1KMT2A | |
| SCHEMBL28181855 | 0.72 | ENPP2 (0.96) | ENPP2MKNK1MKNK2MEN1ALOX15 | |
| SCHEMBL28428741 | 0.72 | ENPP2 (0.96) | ENPP2MKNK1MKNK2MEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4353905-A | CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1982-10-12 | — | — | US | disclosed |