Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.50 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17381155 | 0.82 | RAB9A (0.57) | ALDH1A1CYP1A2CYP2D6CYP2C19TDP1 | |
| SCHEMBL7299435 | 0.81 | ALDH1A1 (0.56) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL696380 | 0.77 | OPRD1 (0.52) | ALDH1A1HSP90AA1HSP90B1HSP90AB1RAB9A | |
| SCHEMBL7300927 | 0.77 | HSP90B1 (0.44) | HSP90AA1HSP90B1HSP90AB1RAB9ANPC1 | |
| SCHEMBL1593910 | 0.74 | SMN1; SMN2 (0.55) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL8503637 | 0.74 | RAB9A (0.55) | ALDH1A1CYP1A2CYP2D6CYP2C19TDP1 | |
| SCHEMBL5851274 | 0.74 | RAB9A (0.53) | TSHRALDH1A1HSP90AA1RAB9ANPC1 | |
| SCHEMBL7289925 | 0.72 | ALDH1A1 (0.47) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1345858 | 0.72 | RAB9A (0.58) | ALDH1A1TDP1HSP90AA1RAB9ANPC1 | |
| SCHEMBL10720116 | 0.72 | LMNA (0.64) | TSHRALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | claimed |
| EP-0300688-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | FISONS plc (GB) | 1989-01-25 | — | — | EP | disclosed |