Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 14/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303501 | 0.92 | ADRB1 (0.49) | ADRB1ADRB2ADRB3KDM4EMEN1 | |
| SCHEMBL7328370 | 0.86 | HRH3 (0.47) | ADRB1HRH3ADRB2ADRB3CYP1A2 | |
| SCHEMBL7305182 | 0.86 | HRH3 (0.46) | ADRB1HRH3ADRB2ADRB3MEN1 | |
| SCHEMBL7335463 | 0.85 | HRH3 (0.54) | ADRB1HRH3ADRB2ADRB3MEN1 | |
| SCHEMBL7397321 | 0.84 | CYP2D6 (0.47) | ADRB1ADRB2ADRB3KDM4EMEN1 | |
| SCHEMBL7306614 | 0.84 | ADRB1 (0.52) | ADRB1HRH3ADRB2ADRB3CYP1A2 | |
| SCHEMBL9686104 | 0.82 | HRH3 (0.43) | ADRB1HRH3ADRB2ADRB3CYP1A2 | |
| SCHEMBL7303996 | 0.82 | CTSS (0.43) | ADRB1ADRB2ADRB3KDM4EMEN1 | |
| SCHEMBL7304010 | 0.82 | PDE3B (0.43) | ADRB1ADRB2ADRB3KDM4EMEN1 | |
| SCHEMBL7304714 | 0.81 | HRH3 (0.46) | ADRB1HRH3ADRB2ADRB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |