Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GRK3 | P35626 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687380 | 0.93 | GPR119 (0.39) | HRH3ADRB3MAPTSMN1; SMN2PDE3B | |
| SCHEMBL7306614 | 0.87 | ADRB1 (0.52) | HRH3ADRB3MAPTSMN1; SMN2PDE3B | |
| SCHEMBL7328370 | 0.83 | HRH3 (0.47) | HRH3ADRB3MAPTSMN1; SMN2ATM | |
| SCHEMBL9687171 | 0.83 | PDE3B (0.41) | ADRB3PDE3BPDE3APDE4APDE4B | |
| SCHEMBL9687154 | 0.83 | GPR119 (0.35) | ADRB3MAPTSMN1; SMN2PDE3BPDE3A | |
| SCHEMBL7299789 | 0.82 | ADRB1 (0.49) | HRH3ADRB3ADRB2ADRB1HTR1A | |
| SCHEMBL7305182 | 0.81 | HRH3 (0.46) | HRH3ADRB3MAPTSMN1; SMN2PDE3B | |
| SCHEMBL7335463 | 0.80 | HRH3 (0.54) | HRH3ADRB3MAPTSMN1; SMN2PDE3B | |
| SCHEMBL7300352 | 0.79 | ADRB1 (0.51) | HRH3ADRB3PDE3BPDE3AGRK3 | |
| SCHEMBL7304714 | 0.78 | HRH3 (0.46) | HRH3ADRB3MAPTSMN1; SMN2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |