Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303255 | 0.92 | GPR119 (0.42) | ADRB2ADRB1HTR1ACYP1A2SLC22A1 | |
| SCHEMBL7328370 | 0.86 | HRH3 (0.47) | HRH3ADRB2ADRB1HTR1ACYP1A2 | |
| SCHEMBL7299789 | 0.86 | ADRB1 (0.49) | HRH3ADRB2ADRB1HTR1ACYP1A2 | |
| SCHEMBL7335463 | 0.85 | HRH3 (0.54) | HRH3ADRB2ADRB1CYP1A2LMNA | |
| SCHEMBL7306614 | 0.82 | ADRB1 (0.52) | HRH3ADRB2ADRB1HTR1ACYP1A2 | |
| SCHEMBL7305060 | 0.82 | PDE3B (0.43) | ADRB2ADRB1HTR1ACYP1A2SLC22A1 | |
| SCHEMBL7305054 | 0.82 | SLC22A1 (0.39) | ADRB2ADRB1HTR1ACYP1A2SLC22A1 | |
| SCHEMBL9686104 | 0.81 | HRH3 (0.43) | HRH3ADRB2ADRB1HTR1ACYP1A2 | |
| SCHEMBL7304714 | 0.81 | HRH3 (0.46) | HRH3ADRB2ADRB1MAPTSMN1; SMN2 | |
| SCHEMBL7329284 | 0.79 | GPR119 (0.45) | ADRB2ADRB1HTR1ACYP1A2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |