Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6759172 | 0.92 | LMNA (0.47) | HPGDHSD17B10ALOX15TSHRLMNA | |
| SCHEMBL6759171 | 0.92 | LMNA (0.47) | HPGDHSD17B10ALOX15TSHRLMNA | |
| SCHEMBL33469 | 0.89 | HCAR2 (0.50) | HPGDHSD17B10ALOX15TSHRKDM4E | |
| SCHEMBL8407382 | 0.82 | MAPT (0.61) | HPGDHSD17B10ALOX15LMNAKDM4E | |
| SCHEMBL23357451 | 0.81 | ALDH1A1 (0.51) | HPGDHSD17B10TSHRKDM4EALDH1A1 | |
| SCHEMBL27571851 | 0.81 | HCAR2 (0.41) | HPGDHSD17B10ALOX15KDM4ESMN1; SMN2 | |
| Methyl Salicylate SCHEMBL27573598 | 0.81 | TSHR (0.79) | HPGDHSD17B10ALOX15TSHRLMNA | |
| SCHEMBL28259523 | 0.80 | ALDH1A1 (0.50) | HPGDHSD17B10TSHRKDM4EALDH1A1 | |
| SCHEMBL240024 | 0.80 | HSD17B10 (0.65) | HPGDHSD17B10TSHRLMNAKDM4E | |
| SCHEMBL28895697 | 0.80 | CA12 (0.53) | HPGDHSD17B10ALOX15KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3697775-A1 | RET9 AND VEGFR2 INHIBITORS | Kala Pharmaceuticals, Inc. (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2019079747-A1 | RET9 AND VEGFR2 INHIBITORS | KALA PHARMACEUTICALS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |
| EP-0679084-A4 | — | — | 1995-11-08 | — | — | EP | disclosed |
| EP-0679084-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO. INC. (US) | 1995-11-02 | — | — | EP | disclosed |
| WO-1994014438-A1 | HYDANTOIN AND SUCCINIMIDE-SUBSTITUTED DERIVATIVES OF SPIROINDANYLCAMPHORSULFONYL OXYTOCIN ANTAGONISTS | MERCK & CO., INC. (US) | 1994-07-07 | — | — | WO | disclosed |
| US-5137904-A | Useful in the treatment of atherosclerosis and thrombosis | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0486280-A2 | Piperidinylcamphorsulfonyl oxytocin antagonists | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| WO-1992007821-A1 | DIASTEREOISOMERS OF BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |