SCHEMBL7300007

SCHEMBL7300007

c1cc2n(c1)-c1sccc1NC2

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.31
GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9382715 0.78 CDK5 (0.37)
SCHEMBL5740273 0.71
SCHEMBL8128105 0.69 DRD2 (0.32) LMNAGLA
SCHEMBL2731241 0.69 BRPF1 (0.44)
SCHEMBL9656030 0.68 PARP1 (0.34)
SCHEMBL15231171 0.67
SCHEMBL19995909 0.66
SCHEMBL5739134 0.66 SIRT6 (0.34)
SCHEMBL9654083 0.66 PNMT (0.32)
SCHEMBL7315748 0.64 KDM4E (0.39) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0573360-B1 Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists ADIR (FR) 1998-08-26 EP disclosed
EP-0573360-A1 Pyrrolothienopyrazine compounds as 5-HT3 receptors antagonists ADIR ET COMPAGNIE (FR) 1993-12-08 EP disclosed