Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.48 |
| ▸ | DHPS | P49366 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298131 | 0.94 | TRPA1 (0.45) | NPBWR1MCHR1TRPA1DHPSLRRK2 | |
| SCHEMBL7294883 | 0.83 | DHPS (0.50) | NPBWR1MCHR1TRPA1DHPSAMY1A | |
| SCHEMBL7293817 | 0.83 | ACHE (0.53) | NPBWR1MCHR1DHPSAURKAENPP1 | |
| SCHEMBL1748457 | 0.82 | DHPS (0.50) | DHPSMEN1ALDH1A1KMT2ANFE2L2 | |
| SCHEMBL7300009 | 0.80 | DHPS (0.51) | NPBWR1MCHR1TRPA1DHPS | |
| SCHEMBL8323293 | 0.78 | CA12 (0.50) | NPBWR1MCHR1KDRPDGFRBPDGFRA | |
| Pyrimidine SCHEMBL628523 | 0.75 | DHPS (0.45) | DHPSMEN1ALDH1A1KMT2ANFE2L2 | |
| SCHEMBL7297932 | 0.75 | HTR1A (0.43) | TRPA1DHPSLRRK2KDRMEN1 | |
| SCHEMBL166380 | 0.73 | NFE2L2 (0.61) | PDGFRBPDGFRAALDH1A1NFE2L2 | |
| SCHEMBL18472613 | 0.73 | NFE2L2 (0.61) | PDGFRBPDGFRAALDH1A1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |