Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | METAP1 | P53582 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 8/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10775299 | 0.93 | METAP2 (0.44) | METAP2METAP1CTSLCTSBCTSS | |
| Hydrochloric Acid SCHEMBL10775294 | 0.93 | METAP2 (0.44) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL469826 | 0.79 | LAP3 (0.47) | CTSBREN | |
| SCHEMBL27724013 | 0.79 | LAP3 (0.47) | CTSBREN | |
| Hydrochloric Acid SCHEMBL3092868 | 0.78 | LAP3 (0.46) | CTSBREN | |
| SCHEMBL9770915 | 0.78 | METAP2 (0.53) | METAP2METAP1CTSLCTSBCTSS | |
| Hydrochloric Acid SCHEMBL10771857 | 0.77 | METAP2 (0.41) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL8243588 | 0.77 | CTSL (0.49) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1859681 | 0.76 | SIGMAR1 (0.48) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1861189 | 0.76 | SIGMAR1 (0.48) | METAP2METAP1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |