Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.47 |
| ▸ | METAP1 | P53582 | 6/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10533232 | 1.00 | METAP2 (0.47) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL9770915 | 0.81 | METAP2 (0.53) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL7352302 | 0.76 | METAP2 (0.60) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL8269724 | 0.76 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1863096 | 0.76 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL12631591 | 0.76 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1863098 | 0.76 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL1863093 | 0.76 | CTSK (0.57) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL7300655 | 0.75 | METAP2 (0.43) | METAP2METAP1CTSLCTSBCTSS | |
| SCHEMBL10521370 | 0.75 | METAP2 (0.52) | METAP2METAP1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |