SCHEMBL7301136

SCHEMBL7301136

CCOC(=O)[C@H]1NCC(=S)C1C(=O)C1CCCCN1C(=O)CCCC1CCC2=C(C=C(C)C(Cl)=CC2)C1

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7293589 0.75
SCHEMBL7293185 0.74 TSHR (0.36) MEN1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL7301966 0.73 HTR1A (0.34) KDM4EALDH1A1
SCHEMBL7302892 0.71 PREP (0.42) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL7301620 0.69 PREP (0.36)
SCHEMBL7302819 0.67 PREP (0.31) KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10
SCHEMBL7293303 0.66 PREP (0.46)
SCHEMBL9048411 0.63 PREP (0.46)
SCHEMBL9046480 0.63 PREP (0.46)
SCHEMBL9046582 0.60 PREP (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed