Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303819 | 0.95 | PDE3B (0.46) | ABCB11MAOAADORA2APDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL7304593 | 0.90 | LMNA (0.45) | ABCB11MAOAADORA2APDE3BPDE3A | |
| SCHEMBL7297387 | 0.88 | ABCB11 (0.40) | ABCB11MAOAADORA2APDE3BPDE3A | |
| SCHEMBL7302583 | 0.87 | MAPT (0.42) | — | |
| SCHEMBL7301195 | 0.83 | HRH3 (0.40) | PDE3BPDE3AGPR119HRH3 | |
| SCHEMBL7297393 | 0.82 | PDE3B (0.47) | ABCB11MAOAADORA2APDE3BPDE3A | |
| SCHEMBL7302590 | 0.81 | MAPT (0.42) | — | |
| SCHEMBL7305054 | 0.81 | SLC22A1 (0.39) | ABCB11MAOAADORA2APDE3BPDE3A | |
| SCHEMBL9687447 | 0.81 | MAPK1 (0.41) | PDE3BPDE3AGPR119 | |
| SCHEMBL7303996 | 0.80 | CTSS (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |