Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | FPR2 | P25090 | 1/20 | 0.59 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292751 | 0.92 | KMT2A (0.55) | KMT2AFPR2NPY5RALDH1A1MMP3 | |
| SCHEMBL10534728 | 0.87 | FPR2 (0.53) | KMT2AFPR2ALDH1A1ALOX15CA2 | |
| SCHEMBL7305859 | 0.86 | KMT2A (0.52) | KMT2AFPR2ALDH1A1OPRD1PPARG | |
| SCHEMBL6897944 | 0.85 | KMT2A (0.61) | KMT2AFPR2LPAR1ALDH1A1ALOX15 | |
| SCHEMBL9834187 | 0.82 | FPR2 (0.59) | KMT2AFPR2ALDH1A1ALOX15CA2 | |
| SCHEMBL7412226 | 0.82 | KMT2A (0.46) | KMT2AFPR2LPAR1NPY5RALDH1A1 | |
| SCHEMBL7301298 | 0.82 | KMT2A (0.48) | KMT2AFPR2ALDH1A1ALOX15CA2 | |
| SCHEMBL6895655 | 0.80 | ITGA4 (0.54) | ITGA4ITGB7 | |
| SCHEMBL7431334 | 0.79 | KMT2A (0.50) | KMT2AFPR2ALDH1A1ALOX15CA2 | |
| SCHEMBL5189503 | 0.79 | FPR2 (0.68) | KMT2AFPR2ALDH1A1ALOX15LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |